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Brandy -> RE: EmilyAnn's baby thread! (5/27/2008 2:50:37 PM)
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I've actually found a few places on that say Class B and to avoid in 3rd trimester as can cause uterine contractions. My midwife said was ok to take though and I took some last night. There is also a concern according to USPharmacist that Benadryl can cause cleft lips and polydatcyly: Chlorpheniramine, clemastine, diphenhydramine, and loratadine are considered pregnancy category B. Brompheniramine and triprolidine are pregnancy category C. The most common concerns about antihistamine use in pregnancy are cleft palate (loratadine and diphenhydramine), polydactyly (diphenhydramine), retrolental fibroplasias, and uterine contractions (diphenhydramine).22 A cause-and-effect relationship for cleft palate and polydactyly could not be established due to small sample sizes. An association was found between antihistamine use in the last two weeks of pregnancy and an increased risk of retrolental fibroplasia. 23 When used in the third trimester, high-dose diphenhydramine may have oxytocic properties. This may cause uterine contractions. Due to lack of information and some theoretical risk, antihistamines should be avoided in the late stages of pregnancy. Add this to my list to talk to midwife about tomorrow.
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